![]() Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Avoid combinationīictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Monitor therapyīaloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. ![]() Consider therapy modificationĪluminum Hydroxide: Citric Acid Derivatives may increase the absorption of Aluminum Hydroxide. Alpha-Lipoic Acid may decrease the absorption of Magnesium Salts. Consider therapy modificationĪlpha-Lipoic Acid: Magnesium Salts may decrease the absorption of Alpha-Lipoic Acid. Drug InteractionsĪlfacalcidol: May increase the serum concentration of Magnesium Salts. Oral solution: Discard remaining medication within 24 hours of opening. Some products may contain potassium and/or sodium. Administer each dose with 8 oz (240 mL) of water. Oral: To increase palatability, chill the solution prior to administration. Dosing: PediatricĬonstipation, occasional: Note: Use of magnesium citrate has generally been replaced with other laxatives (eg, PEG solutions, lactulose) less likely to cause adverse effects (eg, electrolyte disturbances) (Tabbers 2014): Oral solution: Oral:Ĭhildren 2 to 6 years and Adolescents: 4 to 6 mL/kg/day, may administer as a single dose or in divided doses the day before the procedure maximum daily dose: 300 mL/day (NASPGHAN ) Administration Laxative: Oral: Solution: 195 to 300 mL given once or in divided doses Dosing: Geriatricīowel preparation before colonoscopy (off-label use): The ASGE does not recommend use in the elderly (ASGE ) however, some experts suggest that older patients without comorbidities and who cannot tolerate a higher volume preparation may receive magnesium citrate (A-Rahim 2018). Six hours prior to the colonoscopy, administer a second 1 to 1.5 bottle dose followed by clear liquids (three 240 mL glasses) over 1 hour (ASGE A-Rahim 2018). Patient should also be given a clear liquid diet the day prior to the procedure. Split-dose (evening before procedure): Oral: 1 to 1.5 bottles (300 to 450 mL or 10 to 15 oz) in the early evening (ie, between 6 and 8 PM) followed by clear liquids (at least three 240 mL glasses) over 2 hours. Four hours prior to the procedure, administer a second 1.5 bottle dose followed by clear liquids (three 240 mL glasses) over 1 hour (A-Rahim 2018). Single-dose, same-day (for afternoon procedures): Oral: 1.5 bottles (450 mL or 15 oz) taken 8 hours prior to procedure, followed by clear liquids (at least three 240 mL glasses) over 2 hours. ![]() There is no standard dosing for administration the following recommendations are suggested by some experts. OTC labeling: When used for self-medication, do not use if on low salt diet Dosage and Administration Dosing: Adultīowel preparation before colonoscopy (off-label use): Note: This preparation should be avoided in patients with renal impairment, heart failure, decompensated cirrhosis, or baseline electrolyte abnormalities (A-Rahim 2018). A randomized, prospective 2-part study supports use of magnesium citrate as an effective and well tolerated low-volume colonoscopy preparation Berkelhammer 2002. Occasional constipation: Treatment of occasional constipation Use: Off Labelīased on the the American Society for Gastrointestinal and Endoscopy (ASGE) guideline for bowel preparation before colonoscopy, routine use of magnesium citrate as a stand-alone colonoscopy preparation is not recommended for routine use due to limited efficacy data and potential toxicity. Laxative effect: Oral solution: 0.5 to 6 hours Use: Labeled Indications Urine (IOM 1997) feces (as unabsorbed drug) Onset of Action Promotes bowel evacuation by causing osmotic retention of fluid which distends the colon with increased peristaltic activity Pharmacokinetics/Pharmacodynamics Absorption GoodSense Magnesium Citrate: 1.745 g/30 mL (296 mL) Excipient information presented when available (limited, particularly for generics) consult specific product labeling.Ĭitroma: 1.745 g/30 mL (296 mL)
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